Natco Pharma .Ltd company is the manfacture of this drug. Velpanat is a type of class of antiviral drugs that inhibits hepatitis C virus (HCV) from reproduction in the body. Velpanat is combined with other antiviral drugs (ribavirin )in people who suffering from cirrhosis


Epclusa is the generic of Velpanat & is a combination of (velpatasvir 100mg +sofosbuvir400 mg) in fixed dose, and used in adult for the treatment of Hepatitis C virus infection .



Generic Name : Epclusa
Brand Name : Velpanat
Compositions : Velpatasvir and Sofosbuvir
Manufactured By : Natco Pharma .Ltd
Dosage Form : Tablets
Strength : 100 mg of Velpatasvir and 400 mg of Sofosbuvir
Packing : Pack of 28 tablets


Velpanat has common dosage is 400mg, depends upon course ,response and difficulties against the drug dosage may slightily vary for the treatment. Velpanat should administrated orally in same time every day and taken with or without food


Velpanat usually given 12weeks or 24weeks (depends on genotype) along with other combination antiviral drugs to treat HCV Velpanat mainly recommended for adult, In children safety and efficacy of the drug is not established.


According to the weight of the patient Dose of ribavirin: <75kg:1000mg/day Bd ≥75kg: 1200mg/day Bd On the basis of haemoglobin and creatine clearance dosage of ribavirin is decreased.


Any overdose with Velpanat , immediately seek to the emergency medical or poison control department.





with chronic hepatitis C viral infection associated genotype I, II, III, IV, V or VI infection without cirrhosis or with compensated cirrhosis Velpanat is indicated for the treatment of patients who are suffered

"NS5B RNA-dependent RNA polymerase" is an enzyme and its action is inhibited by Sofosbuvir drug and "NS5A" is a protein and its action target by Velpatasvir.its works by reducing the level of hepatitis C virus in the body.


Velpanat is used to treat chronic Hepatitis C infection in adults.
it fights against the infection and helps to improve immune system Easy recover of liver problem
Velpanat with ribavirin use decompensated cirrhosis.

Velpanat tablet composed of sofosbuvir 400mg and Velpatasvir 100mg, its directly helps for replication of hepatitis C virus by blocking the binding of two protein essential.Terminal excretion half life is Sofosbuvir is 25hrs and Velpatasvir is 15hrs.


Signs of allergy with Sofosbuvir and Velpatasvir seek to medical emergency.
Low heartbeat, Shortness of breathing, Low RBC-pale skin,fast heart rate.
Common effects:
Head pain ; feeling tried ; insomnia


In animal studies its effect shown is low and no adverse effect in foetus and in human begins studies are prusing hence its probably safe to use during pregnancy. kindly consult doctor before use.

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• Velpanat used only with the combination of Ribavirin. The patients suffering from severe kidney or liver problems or depression, the drug Sofosbuvir is not recommended treatment.
• Velpanat with Acid reducing agents like Aluminium and magnesium hydroxide,
• H2 receptor antagonist like famotidine, proton pump inhibitors like Omeprazole these drugs are reduce the effect of concentration of Velpatasvir.
• Anticancer drug like topotecan, co administration is not recommended because of elevation of effect of concentration of topotecan




Consult with your doctor Before taking this Velpanat consult with your doctor. If you face any severe side effects also inform the doctor such as: Weekness, Difficulty in concentrating, Shallow breathing, Rapid heart rate, Reduce RBC.
Take it as soon as feasible the missed a dose if u missed it and if time arrives for next dose, then move out missed dose and continue regular schedule. Do not take extra or 2 dose at a time


In animal studies its effect shown is low and no adverse effect in foetus and in human begins studies are prusing hence its probably safe to use during pregnancy. kindly consult doctor before use.
→ Keep Velpanat in its original container and label as child resistance.
→ Store in cool and dry place, incorrect storage lead to less effectiveness
→ Discard the medicine after expiry date
→ Discard the medicine by asking healthcare professional.

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